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DNA methylation levels are age-dependent and can vary over time. When an individual's DNA methylation age is greater than the actual age, this means that the individual is in an age acceleration state, and which may be associated with many aging manifestations, disease development, and even death. DNA Methylation Age AccelerationAge acceleration can be defined as the difference between the DNA methylation age and the actual age, or as the residual resulting from regressing the DNA methylation age on the actual age. In comparison... more

Cancer vaccines represent a promising strategy to induce specific and durable immune responses against tumor antigens (TAs), which are mainly proteins overexpressed in tumor tissue and play a central role in tumor initiation, progression and metastasis. Cancer vaccines have many superior advantages, including minimal non-specific effects, relative non-toxicity, and induction of persistent immunological memory and so on. Compared with standard chemo- and immunotherapies, cancer vaccines have reduced adverse reactions, higher therapeut... more

New research has found that stem cell-derived neurons predict psychosis and cognitive deficits in patients with schizophrenia. In addition, adult neural stem cells play important roles in cognitive functions, including spatiotemporal memory encoding and contextual discrimination, which have been shown to be strongly associated with many psychiatric disorders, such as schizophrenia.Learn more：Neural stem cell characterization

Amino acid composition analysis is the gold standard for accurate quantification of peptides, proteins, antibodies, and other samples. It is often desirable to know the amino acid composition of a sample before finding the sequence information of the sample. A common method for determining amino acid composition is commonly referred to as amino acid analysis, which can be used to determine the amino acid composition, composition, and content of amino acids, peptides, polypeptides, proteins, and antibody samples. Amino acids anal... more

The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that prepare it for the next phase. Cell cycle checkpoints are control mechanisms that ensure that the cell cycle proceeds in a timely and orderly manner. There are three major cell cycle checkpoints:· G1 checkpoint: This checkpoint occurs at the end of the G1 phase. It ensures that the cell has grown to a sufficient size and that... more

Gene editing is one of the latest breakthroughs in biology. The well-known CRISPR-Cas gene editing system confers immunity against foreign DNA to prokaryotes (organisms lacking a cell nucleus). Since the discovery of CRISPR gene editing technology, scientists have revealed how CRISPR-cas proteins evolved from their precursors. This knowledge will help them develop other small new genome editing tools for gene therapy.   At the University of Tokyo, Professor Osamu Nureki's team worked to identify the structure and f... more

Microplastics, a "stealth killer" that threatens the Earth's environment and human health, are now ubiquitous. In previous studies, scientists have found traces of microplastics in environments such as the deep sea, Everest roof, seafood, human placenta, and baby feces. Once such non-degradable particles with a particle size of less than 5 mm enter the human body, it may interfere with the human endocrine system and cause long-term effects on human health. Furthermore, in addition to causing direct harm to the human body, m... more

Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Besides its multifactorial and heterogeneous nature, AD... more

Background of Tau Uptake and SeedingTau proteins are a group of microtubules associated proteins that are mainly located in the central nervous system astrocytes. Tau proteins participate in several biological activities, including regulation of microtubule stabilization and assembly, maintenance of neuronal cytoskeleton, iron export, and axonal transportation. However, tau proteins turn into hyperphosphorylated insoluble aggregates could lead to neurodegenerative tauopathies, such as Alzheimer's disease (AD). The aggregation of tau ... more

Scientists at Creative Biolabs are expert in targeted delivery system research. We have a series of innovative and advanced platforms to provide fast and convenient liposome development services for our worldwide customers. Currently, we can provide affordable, high-quality Ufasomes-based drug delivery services for diseases diagnosis and therapeutic with unbeatable rapid turnaround times.IntroductionUfasomes (unsaturated fatty acid vesicles) are suspensions of closed lipid bilayers that consist of fatty acids, and... more

Creative Biolabs has extensive experience and impressive performance in the field of small molecule drugs and antibody development. With the deepening of the research on small molecule drugs, the demand for anti-drug antibodies is also increasing. Creative Biolabs, relying on its own expertise in these two fields, can provide customers with excellent hapten design and synthesis services to help customers develop better antibodies.Necessity for Development of Antibodies Against SulfonamidesSulfonamides (SAs) are one of the most w... more

Plant growth is driven by light and is powered by photosynthesis of green leaves. The same is true for roots that grow in the dark—they receive the products of photosynthesis, specifically sucrose, or sugar, through a central transport pathway in the phloem. Dr. Stefan Kircher and Prof. Peter Schopfer from the Faculty of Biology at the University of Freiburg have shown in experiments using the model plant Arabidopsis thaliana that sucrose not only ensures the supply of carbohydrates to the roots, but also acts as a signal tran... more

Exosome in AD: Exosomes have been reported to serve as a role in the treatment of many diseases including central nervous system (CNS) disorders. Due to their small size, exosomes are used as effective carriers that deliver therapeutic drugs to target cells or tissues. Besides, mesenchymal stem cells (MSCs)-derived exosomes also play an essential role in CNS diseases therapies.

exosome lyophilization: Lyophilization is a useful technique that can be used for long-term stable preservation of exosomes. Lyophilized exosome standard is easy to transport and storage, and is stable for over 36 months at 4°C. Besides, lyophilized exosome can be used as control standards for FACS, WB, ELISA and other applications, as well as quantitative calibration standards for foreign and domestic exosomes in biological samples.

exosomal rna isolation kits: Exosomes play a critical role in cell-cell communication by shuttling functional protein or nucleic acid molecules in the target cell. They are involved in a variety of pathological processes such as cancer, infectious and neurodegenerative diseases. Increasing evidences have been suggested that exosomal RNA may be involved in the development or progression of specific human diseases. Some pathogenic miRNAs have been investigated as novel therapeutic targets or disease biomarkers in diverse diseases inclu... more

total exosome isolation reagent: Creative Biolabs is very proud of providing the best purification reagents for exosome isolation from urine, biological fluids (i.e., plasma and serum), and cell culture supernatants. The reagents utilize chemical precipitation method to isolate exosomes and the method is simple and timesaving (about 1 hour), does not require special expensive experimental instruments, and only requires centrifuges.

genetically modified T cell: The concept of transferring T cells to patients (adoptive T cell transfers) to treat diseases has been established over the years through ex vivo manipulation, expansion, and reinfusion of T cells targeting specific viruses, for example for the treatment of viral infections, such as cytomegalovirus or Epstein Barr virus infection after hematopoietic stem cell transplantation.

Adnectin-based CAR-T cell:Adnectin can be used as the antigen recognition domain in CAR constructs instead of scFv. We have designed multiple antigen-specific adnectin-CARs. Firstly, mRNA display is used to generate different adnectin clones, which target the target extracellular domain with different affinities. Then, different clones of target-specific adnectins were cloned upstream of the hinge domain to replace the scFv sequence. The adnectin-based extracellular domain is connected by the CD8α hinge and transmembrane domain, CD28... more

Adjuvant Candidate Discovery for Cancer Vaccine: Adjuvants can be added to the vaccines as immune agents to enhance the immune response. The mechanism of adjuvant relies on higher antibody production and longer protection. Here are different ways regarding the mechanisms. By extending the presence of antigen in the blood to expand vaccine protection;By helping bind the antigens of antigen presenting cells to improve the immune response;By supporting the production of cytokines;By activating lymphocytes and macrophages.

oxalobacter formigenes probiotic: One of the most efficient oxalate-degrading organisms is O. formigenes, a Gram-negative, non-pathogenic, anaerobic commensal bacterium, naturally occurring in the colon of humans and other vertebrates and exclusively relying on oxalate to formate conversion as its energy source.