Compound-specific SAs Haptens from Creative Biolabs's blog

Creative Biolabs has extensive experience and impressive performance in the field of small molecule drugs and antibody development. With the deepening of the research on small molecule drugs, the demand for anti-drug antibodies is also increasing. Creative Biolabs, relying on its own expertise in these two fields, can provide customers with excellent hapten design and synthesis services to help customers develop better antibodies.

Necessity for Development of Antibodies Against Sulfonamides

Sulfonamides (SAs) are one of the most widely used antibacterial drugs in the global livestock industry. Most of the SAs drugs contain sulfonylamino groups, and the difference in the R group connected to the N1 position causes the structural differences of each monomer drug. SAs ingested by the human can accumulate in the body, which is not only harmful to the human body, but also causes resistance to many bacteria. Therefore, the EU, the United States, and China have all limited the total amount of SAs and the content of individual SAs in animal products to no more than 0.1 mg/kg. Existing instrument methods can meet the needs of sensitivity for the detection of SAs, but they are slow and inefficient, and not suitable for the detection of a large number of samples. Antibody-based immunoassay technology can replace instrumental methods for the screening and detection of large numbers of samples, and has become a hot spot in the field of residue detection. As a key reagent for immunoassay, the nature of the antibody determines the sensitivity and specificity of the detection method. Therefore, reasonable hapten design and preparation has become a bottleneck problem that restricts the development of antibody preparation technology and obtains ideal antibodies.

Learn more: Compound-specific SAs Haptens