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Alzheimer's disease (AD) presently occupies the topmost position among the most diagnosed neurodegenerative diseases worldwide, with the number of affected people forecasted to reach 100 million by 2050. According to the latest statistics, nearly 44 million people in the world suffer from AD or related dementia, with only one in four being diagnosed with the disease. Currently, the disease has no cure available for its treatment, except for some relief from some of the symptoms. Besides its multifactorial and heterogeneous nature, AD... more

Background of Tau Uptake and SeedingTau proteins are a group of microtubules associated proteins that are mainly located in the central nervous system astrocytes. Tau proteins participate in several biological activities, including regulation of microtubule stabilization and assembly, maintenance of neuronal cytoskeleton, iron export, and axonal transportation. However, tau proteins turn into hyperphosphorylated insoluble aggregates could lead to neurodegenerative tauopathies, such as Alzheimer's disease (AD). The aggregation of tau ... more

Scientists at Creative Biolabs are expert in targeted delivery system research. We have a series of innovative and advanced platforms to provide fast and convenient liposome development services for our worldwide customers. Currently, we can provide affordable, high-quality Ufasomes-based drug delivery services for diseases diagnosis and therapeutic with unbeatable rapid turnaround times.IntroductionUfasomes (unsaturated fatty acid vesicles) are suspensions of closed lipid bilayers that consist of fatty acids, and... more

Creative Biolabs has extensive experience and impressive performance in the field of small molecule drugs and antibody development. With the deepening of the research on small molecule drugs, the demand for anti-drug antibodies is also increasing. Creative Biolabs, relying on its own expertise in these two fields, can provide customers with excellent hapten design and synthesis services to help customers develop better antibodies.Necessity for Development of Antibodies Against SulfonamidesSulfonamides (SAs) are one of the most w... more

Exosome in AD: Exosomes have been reported to serve as a role in the treatment of many diseases including central nervous system (CNS) disorders. Due to their small size, exosomes are used as effective carriers that deliver therapeutic drugs to target cells or tissues. Besides, mesenchymal stem cells (MSCs)-derived exosomes also play an essential role in CNS diseases therapies.

exosome lyophilization: Lyophilization is a useful technique that can be used for long-term stable preservation of exosomes. Lyophilized exosome standard is easy to transport and storage, and is stable for over 36 months at 4°C. Besides, lyophilized exosome can be used as control standards for FACS, WB, ELISA and other applications, as well as quantitative calibration standards for foreign and domestic exosomes in biological samples.

exosomal rna isolation kits: Exosomes play a critical role in cell-cell communication by shuttling functional protein or nucleic acid molecules in the target cell. They are involved in a variety of pathological processes such as cancer, infectious and neurodegenerative diseases. Increasing evidences have been suggested that exosomal RNA may be involved in the development or progression of specific human diseases. Some pathogenic miRNAs have been investigated as novel therapeutic targets or disease biomarkers in diverse diseases inclu... more

total exosome isolation reagent: Creative Biolabs is very proud of providing the best purification reagents for exosome isolation from urine, biological fluids (i.e., plasma and serum), and cell culture supernatants. The reagents utilize chemical precipitation method to isolate exosomes and the method is simple and timesaving (about 1 hour), does not require special expensive experimental instruments, and only requires centrifuges.