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DNA modifying enzymes play a key role in the development of various medical and industrial applications. An important tool for analyzing the activity and specificity of these enzymes is clustering analysis. Cluster analysis is a bioinformatics technique involving the grouping of related sequences based on similarity. Cluster analysis allows researchers to group similar enzyme sequences and identify conserved patterns that are critical to enzyme function. This information can be used to develop more efficient enzymes or improve existi... more

Transfer lipopolysaccharide activates monocytes through TLR4, which is thought to increase the risk of cardiovascular disease in HIV-infected individuals. Recently, in a study published in Communications Biology entitled "mTOR regulation of metabolic limits of LPS-induced monocyte inflammatory and procoagulant responses," scientists from the State University of New York at Upstate Medical University found that therapeutic inhibition of a metabolic regulator in monocytes may unexpectedly increase the level of inflammatory signals... more