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What is Codeine?

Codeineis an opioid pain medication used to treat mild to moderate pain. It is classified as a narcotic drug and works by changing the way the brain and nervous system respond to pain. Codeine is often used in combination with other medications, such as acetaminophen, to provide additional pain relief. It can also be used to treat coughing and diarrhea. Codeine can be habit-forming and is only available by prescription.

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How does it work?

Codeine works by binding to specific receptors in the brain and spinal cord known as mu, kappa, and delta opioid receptors. This binding activates the receptors, leading to a decrease in the perception of pain and an increase in the release of certain neurotransmitters, such as dopamine and norepinephrine, that produce a feeling of euphoria or relaxation. Codeine also slows down the activity of the central nervous system, which can cause drowsiness and reduce the coughing reflex. The exact mechanism of action for codeine is not fully understood, but it is thought to work by inhibiting the transmission of pain signals in the brain and spinal cord.

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How to take it?

Codeine is typically taken orally, in the form of a tablet, capsule, or syrup. The dosage, frequency, and duration of use will depend on the specific condition being treated and the individual's response to the medication. It is important to follow the instructions of your healthcare provider and the label on the medication bottle when taking codeine.

Here are some general guidelines for taking codeine:

  • Take the medication exactly as prescribed by your doctor.

  • Do not crush, break, or chew extended-release tablets.

  • If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule.

  • Do not take codeine in larger or smaller amounts or for longer than recommended.

  • Do not stop taking codeine suddenly, as this can cause withdrawal symptoms. Your doctor will gradually decrease your dose if it is necessary to stop taking the medication.

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Side Effects

Codeine can cause a variety of side effects, some of which are mild and others that can be more serious. The most common side effects of codeine include:

  • Drowsiness

  • Nausea and vomiting

  • Constipation

  • Dizziness

  • Headache

  • Sweating

  • Dry mouth

  • Itching

  • Lightheadedness

  • Mood changes

In some cases, codeine can also cause more serious side effects, such as:

  • Respiratory depression, which can be life-threatening

  • Confusion and disorientation

  • Hallucinations

  • Seizures

  • Slow or shallow breathing

  • Extreme drowsiness or coma

  • Hives, rashes, or itching

  • Swelling of the face, lips, tongue, or throat

If you experience any of these serious side effects, seek medical attention immediately. If you have any concerns about the side effects of codeine, talk to your doctor or pharmacist. They can advise you on the best course of action and whether you should continue taking the medication.


There are several precautions to keep in mind when taking codeine, including:

  • Allergies: If you have a history of allergic reactions to codeine or any other medications, let your doctor know before taking codeine.

  • Other medical conditions: Before taking codeine, tell your doctor if you have any medical conditions, such as liver or kidney disease, breathing problems, head injury, low blood pressure, or a history of alcohol or drug abuse.

  • Pregnancy and breastfeeding: Codeine should be used with caution during pregnancy and breastfeeding. It is not recommended for use during the first trimester of pregnancy and should be used with caution during the latter stages of pregnancy and while breastfeeding.

  • Interactions with other medications: Codeine can interact with other medications, including sedatives, tranquilizers, sleeping pills, muscle relaxants, and other pain medications. Let your doctor know about all the medications you are taking before starting codeine.

  • Alcohol: Alcohol can increase the sedative effects of codeine and should be avoided while taking the medication.

  • Overdose: Taking too much codeine can cause serious health problems, including respiratory depression, coma, and death. If you suspect an overdose, seek medical attention immediately.

It is important to follow the instructions of your healthcare provider and the label on the medication bottle when taking codeine. If you have any questions or concerns about the medication, talk to your doctor or pharmacist.

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